AKT1 and neoplasm: In addition, the phosphorylation of PTENSer380 (a lipid phosphatase that acts as a tumor suppressor by targeting the PI3K/AKT pathway) was inhibited in gRNA-4-treated cells compared to the controls, indicating HIV-induced activation of the PI3K/AKT signaling is attenuated in gRNA-4-treated cells (Figure 5).