The protease separase, necessary for cohesion cleavage and allowing of chromosomal segregation during anaphase [49], is also up regulated under the SlaGemV−1 infection in the cabbage leaf curl virus (CLCV) Begomovirus, a bipartite geminivirus, the endocycle was induced by modifying the expression of cyclin D3 family members, which regulate CDKs during G1 phase and interact with the plant RBR-E2F system to encourage polyploidy and replication of the viral genome without mitosis [44]. This evidence concerns the gene CCND3 and infection.