BI-D EC50 values to inhibit the early versus late phase of HIV-1 replication are ~2.4 μM [44,53] and 0.9 μM [61], respectively, and previous work showed that LEDGF/p75 depletion significantly increased BI-D’s potency to inhibit the early phase of infection [44,61]. Here, PSIP1 is linked to infection.