This compound selectively inhibited proliferation of the MCPyV sT-expressing mouse fibroblast cell line, implicating the promising antitumor activity of MeSG in VP-MCC and potentially other human skin cancers such as melanoma with activated MAPK and PI3K/AKT signaling [10], which will open new opportunities for clinical research. This evidence concerns the gene AKT1 and Merkel cell skin cancer.