The role of Tregs in the progression of colon cancer is controversial: it was shown that Tregs present antitumor immunity through the production of cytokines, such as TGF-β in the early stage, while the infiltration of tumors by Tregs confers growth and metastatic advantages by inhibiting antitumor immunity as the stage progresses [41]. Here, TGFB1 is linked to malignant colon neoplasm.