In another study, the expression of CXCL11 on VACV also showed an enhanced therapeutic efficacy without affecting virus infection and replication, displaying increased local numbers of CD8+ CTLs as well as reduced expression of several suppressive molecules such as TGF-β, COX2, and CCL22 in the tumor microenvironment (TME), thus prolonged the survival of mice with a murine AB12 mesothelioma model [54]. This evidence concerns the gene CD8A and neoplasm.