Utilizing leftover cryopreserved PBMC samples from the adjuvanted FLU-v group and adjuvanted placebo from the above-mentioned clinical phase IIb trial [5], we aimed to explore vaccine-induced effector functions and cross-reactive cellular immunity by means of measuring IFN-γ- and granzyme-B-producing cells by dual ELISpot assay in response to a panel of diverse influenza strains. The gene discussed is GZMB; the disease is influenza.