The main, but not only, sources of IFN-γ found in P. falciparum infection include Th1 cells, cytolytic CD8 T cells, NK cells and γδ T cells [304], in particular Vδ2+ γδ T cells [265], as high production of pro-inflammatory cytokines by Vδ2+ γδ T cells has been shown to protect from infection by P. falciparum in children living in a high transmission setting. The gene discussed is CD8A; the disease is infection.