With the development of B cell tetramers [97] and BCR-transgenic mice [132] to identify malaria-reactive B cells, mouse models of malaria will be needed for moving forward the analysis and definition of factors that influence a robust and efficacious humoral response with the precision required to identify more relevant metrics to signify efficacious candidate vaccines against malaria that elicit a long-lived protective response. Here, BCR is linked to malaria.