In addition, to test if the stemness and immune-relevant genes were involved in oral cancer, Lin et al. established an eight-gene risk model (ESCO2, CCNA2, COL5A3, RCN3, LMCD1, FMNL3, MMP14, and HEYL), which performed well in predicting overall survival and recurrence-free survival in OSCC patients [17]. This evidence concerns the gene COL5A3 and lip and oral cavity carcinoma.