A moderate correlation was observed between frequencies of FoxP3+ Tregs and CD4+LAG-3+ T cells in PBMCs of CRC patients, and it was found to be stronger in advanced tumor stages compared to early stages (r = −0.022, p = 0.945 [early]; r = 0.488, p = 0.039 [advanced]). This evidence concerns the gene LAG3 and neoplasm.