CD4 and neoplasm: With regards to the less suppressive/stable FoxP3+Helios− Tregs, a moderate correlation was found between frequencies of these Tregs and CD4+PD-1+ T cells in PBMCs of patients with advanced tumor stages (r = −0.188, p = 0.557 [early]; r = 0.499, p = 0.035 [advanced]), and a strong correlation in the TME of patients with advanced tumor stages (r = 0.573, p = 0.106 [early]; r = 0.635, p = 0.019 [advanced]), and in NILs in patients with early stages (r = 0.660, p = 0.043 [early]; r = 0.370, p = 0.235 [advanced]) (Figure 3A).