PDCD1 and neoplasm: Conversely, negative correlations were found between frequencies of FoxP3−Helios− T cells and CD4+PD-1+ T cells in the TME in patients with early and advanced tumor stages (r = −0.662, p = 0.052 [early]; r = −0.576, p = 0.039 [advanced]) (Figure 4A), and in NILs the correlation was stronger in early tumor stages, compared to advanced stages (r = −0.709, p = 0.026 [early]; r = −0.430, p = 0.162 [advanced]) (Figure 4A).