FOXP3 and neoplasm: Moreover, strong negative correlations were found between frequencies of FoxP3-Helios- non-Tregs and CD4+TIM-3+ T cells in TILs, and they were found to be stronger in advanced tumor stages compared to early stages (r = −0.751, p = 0.019 [early]; r = −0.812, p = 0.0007 [advanced]) (Figure 4B).