CD4 and colorectal carcinoma: We have recently reported that some ICs, including T cell immunoglobulin and mucin domain-containing protein-3 (TIM-3), cytotoxic T lymphocyte-associated antigen-4 (CTLA-4), programmed cell death-1 (PD-1), and lymphocyte-activation gene-3 (LAG-3), were upregulated on CD4+ T cells, and they play roles in CRC disease progression [7].