Precisely these cytokines, such as IFN-alpha, IFN-gamma, and CXCL10/IP10, peculiar of Th1-type immune response, play a crucial role in the pathogenesis of autoimmune thyroid diseases, including GD and Graves’ ophthalmopathy (GO) [58,59,60,61,62]. The gene discussed is IFNG; the disease is autoimmune thyroid disease.