Akt 1 is a kinase involved in the processes of tumor cell proliferation and migration, and two examples, brome mosaic virus (BMV) and cowpea chlorotic mottle virus (CCMV) loaded with the antitumor siRNA Akt1 (siAkt1), have shown to be capable of being internalized by the tumor cells and thus, able to deliver the siAkt1 cargo into breast tumor cells [49]. This evidence concerns the gene AKT1 and neoplasm.