ACE and cardiac hypertrophy: Phenolic compounds present in coffee roasting waste have attributed antioxidant effects that contribute to the prevention of cardiovascular injury through the inhibition of oxidative stress related to cardiac hypertrophy, as well as the modulation of antihypertensive pathways, such as the reduction of circulating angiotensin II by inhibiting the angiotensin converting enzyme (ACE), and the inhibition of HMG-CoA reductase, a crucial enzyme in the synthesis of cholesterol [22,23].