Specifically observed in APL cell lines (NB4) p-53 induction and p27KIP1 regulation of tumour development driver genes, Bcl-2 and Bax, can be seen seen where the Bcl-2/Bax complex is translocated to the mitochondria after ATO treatment, causing cell cycle inhibition [24]. Here, TP53 is linked to acute promyelocytic leukemia.