RPE65 and Leber congenital amaurosis: Although there are no clinical trials employing organic NPs to deliver genes to treat inherited retinal diseases yet, Sun et al. showed that nanolipids integrated into DNA can efficiently deliver the Rpe65 gene into the retinal pigmented epithelium in the Leber congenital amaurosis (LCA) model of Rpe65−/− mice to restore vision [63].