- Self-assembled Smac-TLR7/8 peptide hydrogel that can repolarize tumor-associated macrophages into M1 type for improving anticancer immune responses by relieving radio-resistant TME.- Modulating the ITM and overcoming the radioresistance by reprogramming TAMs polarization toward the M1 phenotype.- Improving radio sensitivity and reducing the radiation dose due to the Smac mimetic peptide. This evidence concerns the gene TLR7 and neoplasm.