Activation of Glycogen Synthase Kinase-3 beta (GSK3β), a crucial insulin mediator, may be Akt-dependent or direct; nevertheless, metabolic effects should be expected after manipulation of Ang (1-7), and indeed, oral administration of coated peptide attenuates hyperglycaemia in type 2 diabetes mellitus rodents showing impaired insulin sensitivity [33,34]. Here, INS is linked to Hyperglycemia.