Therefore, we constructed a risk scoring system using both demographic factors and genetic factors, which remained in Model II; overdose, rivaroxaban, anemia, ABCB1 rs3842, APOB rs693 and APOB rs13306198 were taken as 2, 1, 1, 1, 3 and 1 point, respectively. The gene discussed is APOB; the disease is anemia (phenotype).