INS and type 1 diabetes mellitus: Three major umbrellas of diabetes include autoimmune mediated beta-cell-specific destruction—type 1 diabetes mellitus (T1D) mellitus, metabolic exhaustion of pancreatic endocrine cells due to acquired insulin resistance—type 2 diabetes (T2D) mellitus, and the breakdown of insulin-producing cells by inflammatory effects of chronic exocrine pancreatic disease in type 3c diabetes (T3cD) mellitus [1,2,3].