CD8A and neoplasm: Additionally, though the activation of specific immune response by VDA@Gel was not so obvious (12.6% CD8+ T-lymphocytes), its effect on regulating the Treg and MDSCs cells was strong as the Treg and MDSCs cells in tumor tissues from VDA@Gel group were decreased by 16.3% and 14%, respectively, in comparison with the saline group.