TNF and inflammatory bowel disease: The general goals of anti-TNF-α therapy in IBD can be summarized as follows: (i) inducing sustained endoscopic mucosal healing/endoscopic remission (as the primary endpoint), (ii) maintaining deep clinical remission (i.e., corticosteroid-free remission), (iii) preventing and reducing related complications of IBD disease, and (iv) improving the quality of life of IBD patients [91].