CCND2 and diffuse intrinsic pontine glioma: Further, H3K27M is closely related to other mutations in DIPG, such as H3.1K27M-related ACVR1 mutation (25% of DIPG) and H3.3K27M-related amplified mutations in CCND2, PDGFRA (30% of DIPG), TP53 (75% of DIPG), and MYC [36,44,45,46].