This suggests that, in elderly patients and those with metabolic disorders such as obesity, hyperglycemia, insulin resistance, or MetS, who already have a compromised innate and humoral immune system due to their comorbidities, ACE-2 over-expression may contribute to an increased susceptibility to SARS-CoV-2 infection and the severe course of disease [80]. This evidence concerns the gene ACE2 and Insulin resistance.