However, The A549 cell line used in our study is a human lung cancer cell line, and therefore cytotoxicity with ceragenins and AMPs may be higher than with primary cell lines since AMPs and ceragenins show increased cytotoxic activity against transformed cells such as cancer cells and IB3-1 (cystic fibrosis lung cells) and are therefore considered as anticancer agents [18,19]. The gene discussed is ADSL; the disease is cystic fibrosis.