Interestingly, although at baseline our study had the frequencies of MTB-specific CD4+ T-cells expressing CD38, HLA-DR and Ki67 in HIV/TB coinfected patients similar to other studies [16,17], we observed that our cohort had lower frequencies of MTB-specific CD4+ T-cells expressing HLA-DR compared to the study by Riou et al. (2020) [13]. Here, CD4 is linked to tuberculosis.