Interestingly, the c-MYC gene is found in the chromosomal region most commonly impacted by HPV genome integration (8q24), and c-myc overexpression was found to correlate with HPV amplification, making it a potential biomarker for cervical cancer [52,53] Another E6 substrate is the apoptosis-inducing factor (AIF), a pro-apoptotic flavoprotein involved in the mitochondrial apoptotic pathway, which E6 also binds and targets for degradation [54]. The gene discussed is MYC; the disease is cervical carcinoma.