They demonstrated that these SNPs are one of the plausible mechanisms underlying mastitis by modulating the interaction of miRNAs and immune-related genes such as the Spi-1 proto-oncogene (SPI1), which is a vital regulator of the innate and adaptive immune systems; and that the SNPs, including the confirmed rs109462250 SNP of miR-2899 (in the study), may have implications for the mastitis resistance breeding program in cattle. This evidence concerns the gene SPI1 and mastitis.