In our model, we observed hyperplasia of type 2 alveolar epithelial cells (main source of SPD in the lung) in both WT and TLR9-/- infected mice 21 days after C. gattii inoculum, which is associated with a mice model of pulmonary fibrosis [62] and idiopathic pulmonary fibrosis [53]. This evidence concerns the gene TLR9 and pulmonary fibrosis.