To investigate the role of the Rv2387 protein on NF-κB and MAPK signaling, we performed an immunoblot assay of expression and phosphorylation of ERK, p38, JNK, and NF-κB p65 upon either recombinant Msmg-2387 or Msmg-EV strain infections. The gene discussed is NFKB1; the disease is infection.