Kim and colleagues in 2021 demonstrated that chrysin had antiviral activities against influenza by inhibiting the autophagy, a process that helps cells to degrade the pathogens in the innate immune response and leads to the viral clearance, but it is also a process that is replicated and used by some viruses, such as influenza A. Chrysin increased the cell viability, reduced the hemagglutinin and blocked the autophagy (shown by the reduction of the LC3 autophagosome and the increase in the mTOR protein levels) in infected A549 cells treated with 50 μM chrysin for 24 h [39]. This evidence concerns the gene MAP1LC3A and influenza.