Many aspects such as frizzled-related protein 1 (sFRP-1)/Wnt/β-catenin, phosphatidylinositol 3-kinase/protein kinase B/glycogen synthase kinase-3β (PI3K/Akt/GSK-3β), and hypoxia-induced mitogenic factor-interleukin 6 (HIMF-IL-6) signaling pathways, which have a significant role in myocardial fibrosis regulation [22], are yet to be studied. The gene discussed is AKT1; the disease is Myocardial fibrosis.