Blood transfusions, the use of drugs that stimulate erythropoiesis, chemotherapy, autoimmune diseases, thrombophilia (Factor V Leiden gene mutation, activated protein C resistance, prothrombin gene mutation (G 20210 A), AT3 deficiency, protein C and S deficiency, elevated values of lipoprotein), the presence of a central venous catheter, heart failure, stroke, the postpartum period, as well as infections are classified as moderate risk factors [4]. The gene discussed is F5; the disease is autoimmune disease.