P4HA1 and liver cancer: Recently, there was study reporting that the P4HA1 expression was increased in clear cell renal cell carcinoma compared to adjacent normal tissues [16], and P4HA1 was substantially overexpressed in 26 of 33 cancers types, including liver cancer, pancreatic cancer, and stomach cancer; P4HA1 overexpression was associated with poor survival in these patients [17].