Figure 5A,B show that the proliferation of the three CRC cells was inhibited significantly after being treated with oxaliplatin, and the mRNA expression of COPE, P4HA1, ATF6, IBTK, and PHLDB3 showed a large change in the oxaliplatin-treated group compared with the control groups in all three cell lines (Figure 5C–E). The gene discussed is P4HA1; the disease is colorectal carcinoma.