AKT1 and chronic myelogenous leukemia, BCR-ABL1 positive: We have previously reported that TQ exerted anti-leukemia effects by inducing antiproliferative effects and enhancing apoptosis in MV4-11 AML cells and K562 CML cells and through hypomethylation of JAK/STAT and PI3K/Akt/mTOR-negative regulator genes in MV4-11 AML cells [27,32].