REN and hypertensive disorder: In addition to the most widely used models, many others that reflect some features of hypertension can be found, such as TGR(mRen2)27, in which overexpression of the renin gene is induced, adrenal regeneration hypertension (ARH), in which contralateral adrenal enucleation is performed, and metacorticoid hypertension, which is similar to DOCA-salt but with more stable development of hypertension or renal hypertension (so-called two-kidney, one clip (2K1C), where the renal artery is constricted [29,31,32].