Custodio de Souza Oliveira et al. [55] compared the efficiency of SiO2 NPs functionalized with 3-(2-aminoethylamino)propyl groups (SiNP-AAP) either with covalently bound RB (SiNP-AAP-RB) or 9,10-anthraquinone-2-carboxylic acid (SiNP-AAP-OCAq) against human lung carcinoma A549 cells. This evidence concerns the gene RB1 and lung carcinoma.