The four effective ingredients in DH (tanshinol, salvianolic acid A, salvianolic acid B, and hydroxysafflor yellow A) have exhibited a protective effect on rats with cerebral ischemia/reperfusion injury, potentially through the inhibition of apoptosis via the downregulation of key targets upstream of the caspase-3 pathway [26]. This evidence concerns the gene CASP3 and Cerebral ischemia.