Moreover, failure or impairment of autophagy in cells may cause an accumulation of soluble or aggregated tau protein, a decreased level of Beclin–1, and finally the increased expression of amyloid precursor protein (APP) and β–amyloid, which are related to the pathogenesis of Alzheimer’s disease and oxidative stress conditions [7]. The gene discussed is APP; the disease is early-onset autosomal dominant Alzheimer disease.