Amentoflavone also showed potential anti-diabetic activity by regulating glucose and lipid metabolism by decreasing levels of glucose, total cholesterol, triglyceride, low-density lipoprotein cholesterol (LDL-C) and glucagon, and increasing levels of high-density lipoprotein cholesterol (HDL-C) and insulin [63] in addition to promoting protective effects against cardiovascular dysfunction and liver damage in rats with induced metabolic syndrome. This evidence concerns the gene INS and metabolic syndrome.