↑ Tmem119+; ↓ genes related to AD-associated microglia; ↓ infiltration of CD8+ T-cells into the brain parenchyma; ↑ cognitive functions; ↓ 1061 genes (e.g., Gpr17, Entpd1, Mlec); ↑ 744 genes (e.g., Zfp46, Ciart, Dbp); more pronounced effect in females. The gene discussed is ENTPD1; the disease is Alzheimer disease.