The most common disorders are amyloidoses, tauopathies, α-synucleinopathies, and transactivation response DNA binding protein 43 (TDP-43) proteinopathies, which may cause movement or functional problems, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Lewy body disorders, and amyotrophic lateral sclerosis, among others [223]. The gene discussed is TARDBP; the disease is Parkinson disease.