CRP and respiratory failure: Our study identified many of these pathophysiological elements in the three waves of the pandemic, including anorexia (23.8%), vomiting and nausea (8.9%), diarrhea (30.1%) and reduced food intake (40.5%); respiratory failure requiring orotracheal intubation or ventilation with nasal intermittent positive pressure ventilation (12.2%); catabolic changes due the host inflammatory response phase; as well as high acute inflammation with CRP values between 7.7 and 10.2 mg/dL.