The results showed that pre-infestation dietary supplementation with BL significantly suppressed the elevation of pro-inflammatory cytokines TNF-α, IL-1β, and IFN-γ caused by CR, suggesting that BL supplementation before CR infestation improved splenomegaly associated with a decrease in circulating pro-inflammatory cytokines (Figure 3). The gene discussed is IFNG; the disease is Splenomegaly.