However, in the current study, based on the four SNPs (rs12953258, rs2280148, rs4969168 and rs4969170) of SOCS3 as instrumental variables, the Mendelian randomization analyses found a causal association between methylation levels of SOCS3 and abdominal obesity, which suggested that the SOCS3 gene might play a role in the pathogenesis of abdominal obesity and could be potentially used as a marker for attenuated or aggressive disease in the Asian population. This evidence concerns the gene SOCS3 and Abdominal obesity.