Hence, a study for the evaluation of the circulating levels of PIIINP and NOX2, as potential non-invasive biomarkers of fibrosis in 25 NAFLD children enrolled in the 4-month interventional study with HXT-VitE and who participated to a long-term follow-up study (24 months from the end of treatment), were designed. Here, CYBB is linked to metabolic dysfunction-associated steatotic liver disease.