ECM1 and ovarian carcinoma: To further determine how ECM1 is regulated in ovarian cancer cells, we analyzed the promoter region of ECM1 and found that two motifs located at nucleotides (nt) −890 to −881 (GGGagacCCC, named EP881C) and at −275 to −266 (GGGagatCCC, named EP266C) upstream of the transcription start site were potential p65 binding sites [32].