According to a previous study [216], genistein treatment (2 and 4 mg/kg/day for 10 days) can also improve aging-induced kidney injury in male rats by decreasing age-related NF-κB activity (activated by angiotensin II during senescence) and the expression of downstream pro-inflammatory genes, which indicated that genistein had an obvious anti-inflammatory effect by inhibiting the activation of NF-κB induced by angiotensin II during aging. The gene discussed is AGT; the disease is kidney injury.