In another study, genistein (15 mg/kg body weight, i.p.), administered 30 min before ischemia and 1 h after ischemia, reduced kidney injuries in kidney I/R (45 min/24 h) rats by reducing the inflammation response (decreasing TLR-4 and TNF-α expression) and oxidative stress (intensifying antioxidant ability) [148]. Here, TLR4 is linked to ischemia.