In a study in a non-alcoholic steatohepatitis mouse model, the hot water extract of C. longa inhibited the hepatic production of TNF-α, IL-1β, and IL-6 [26], and in our earlier clinical studies, C. longa extract improved systemic inflammatory markers, including hsCRP, TNF-α, and IL-6 [27,28]. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.