CNR1 and colorectal carcinoma: These findings are in line with a previous study that showed higher rate of Cnr1 methylation in human CRC (77%) compared to hypermethylation of tumor suppressor and repair genes DNA, such as the cyclin-dependent kinase inhibitor P16/INK4a, P14/ARF, APC, hMLH1, and MGMT, which are methylated in a few cases (10–30%) [15].