SLC5A2 and chronic kidney disease: It has been demonstrated that NH3 and SGLT2 can regulate each other; consequently, all those events characterizing diabetic conditions (i.e., low luminal glucose, the overactivation of the sympathetic nervous system, acidosis, oxidative stress, chronic kidney disease, and congestive heart failure (CHF)), contribute to inducing primarily NH3 and enhance SGLT2 expression [60].