NFKBIA and hereditary elliptocytosis: In addition, the data showed that the mRNA expression of NF-κB in the HE group was significantly higher than that in the HS group (Figure 6E; p < 0.0001), and aerobic exercise significantly decreased the levels of NF-κB and remarkably increased the protein level of IκB-α (p < 0.0001), suggesting that aerobic exercise could reduce skeletal muscle inflammation by the NF-κB signaling pathway.