AKT1 and hereditary elliptocytosis: According to our study, although there were no significant differences found in the protein expression in the phosphorylation of AKT protein between HE mice and control mice, inhibited IRS-1/PI3K/AKT pathway and GLUT4 protein content were observed in the skeletal muscles of the HFD mice, and aerobic exercise reversed the inactivation of the pathway.